Interactions between PIAS proteins and SOX9 result in an increase in the cellular concentrations of SOX9.
PIAS1
PIAS2
COLLAGEN, TYPE II, ALPHA-1; COL2A1
Aminoacids composition
STAT1
[DISEASE] Defects in STAT1 are the cause of STAT1 deficiency
[MIM:600555]. Patients generally suffer from mycobacterial or viral
diseases. In the case of complete deficiency, patients can die of
viral disease.
[DISEASE] Defects in STAT1 are a cause of mendelian susceptibility
to mycobacterial disease (MSMD) [MIM:209950]; also known as
familial disseminated atypical mycobacterial infection. This rare
condition confers predisposition to illness caused by moderately
virulent mycobacterial species, such as Bacillus Calmette-Guerin
(BCG) vaccine and environmental non-tuberculous mycobacteria, and
by the more virulent Mycobacterium tuberculosis. Other
microorganisms rarely cause severe clinical disease in individuals
with susceptibility to mycobacterial infections, with the exception
of Salmonella which infects less than 50% of these individuals. The
pathogenic mechanism underlying MSMD is the impairment of
interferon-gamma mediated immunity whose severity determines the
clinical outcome. Some patients die of overwhelming mycobacterial
disease with lepromatous-like lesions in early childhood, whereas
others develop, later in life, disseminated but curable infections
with tuberculoid granulomas. MSMD is a genetically heterogeneous
disease with autosomal recessive, autosomal dominant or X-linked
inheritance.
Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment 2007
STAT3 Regulates Cytokine-mediated Generation of Inflammatory Helper T Cells
