Competition for RXR
RXR and its Brothers

Author: Gianpiero Pescarmona
Date: 06/08/2018


Working hypothesis

The basic idea is that RXR heterodimerizes with nuclear receptors including CAR, FXR, LXR, PPAR, PXR, RAR, TR, and VDR to promote transcription of the downstream target gene into mRNA and eventually protein.

RXR amount is the limiting factor driving the total amount of proteins that a specific cell can synthesize.
The competition for RXR by liganded receptors will drive the choice of the proteins to be synthesized.

RXR scarcity can derive from:

  1. absolute lack of RXR (diet poor in proteins??)
  2. relative lack due to sequestration of RXR by an increased number of a specific liganded receptor (TR, VDR; RAR etc)


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