RXR and its Brothers
Transcription Factors

Author: Gianpiero Pescarmona
Date: 17/07/2011

Description

DEFINITION

A short protein description with the molecular wheight, isoforms, etc...
Use, when available, the link to Wikipedia (Es Trypsin)

External links not available on Wikipedia have to be added here

THE GENE

DatabaseLink
WikigenesACADM
GeneCards"URL":
Your Favorite Gene Sigma"URL":

CHEMICAL STRUCTURE AND IMAGES

When relevant for the function

  • Primary structure
  • Secondary structure
  • Tertiary structure
  • Quaternary structure

Protein Aminoacids Percentage (Width 700 px)

SYNTHESIS AND TURNOVER

mRNA synthesis
protein synthesis

post-translational modifications
degradation

CELLULAR FUNCTIONS

cellular localization,

  • intracellular

biological function

Transcription Factors

Signalling through nuclear receptors, 2002

  • homodimers??
  • heterodimers
    • Liganded
    • Unliganded

Competition for RXR

As all these factors are active as heterodimers with RXR, RXR availability can became a limiting factor for hormones activity.

RXR scarcity can derive from:

  1. absolute lack of RXR (diet poor in proteins??)
  2. relative lack due to sequestration of RXR by an increased number of a specific liganded receptor (TR, VDR; RAR etc)
DatabaseLink
BRENDA - The Comprehensive Enzyme Information System"URL":
KEGG Pathways"URL":
Human Metabolome Database"URL":

REGULATION

DIAGNOSTIC USE

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