Role of glutathione biosynthesis in endothelial dysfunction and fibrosis.
Highlights
- Endothelial haplo-insufficiency of GCLc increases basal and stimulated ROS levels.
- Decreased endothelial GSH promotes eNOS S-glutathionylation.
- Endothelial GSH reduction impairs endothelium-dependent vasodilation in male mice.
- Reduced endothelial GSH levels promotes renal fibrosis.
