Nrf2-ARE pathway
Transcription Factors

DEFINITION

A short protein description with the molecular weight, isoforms, etc...
Use, when available, the link to Wikipedia (Es Trypsin)

External links not available on Wikipedia have to be added here

THE GENE

Database	Link
HGNC	ACADM
Uniprot	"URL":

HGNC includes links to

• BioGPS
• GENATLAS
• GeneCards
• GOPubmed
• H-InvDB
• QuickGO
• Reactome
• Wikigenes includes links to
  • NCBI
  • NCBI SNP
  • iHOP resource
  • OMIM
  • UniProt
  • Ensembl
  • HGNC

CHEMICAL STRUCTURE AND IMAGES

When relevant for the function

• Primary structure
• Secondary structure
• Tertiary structure
  • PDB
• Quaternary structure

Protein Aminoacids Percentage
The Protein Aminoacids Percentage gives useful information on the local environment and the metabolic status of the cell (starvation, lack of essential AA, hypoxia)

Protein Aminoacids Percentage (Width 700 px)

SYNTHESIS AND TURNOVER

mRNA synthesis
protein synthesis

post-translational modifications
degradation

CELLULAR FUNCTIONS

An overview of chemical inhibitors of the Nrf2-ARE signaling pathway and their potential applications in cancer therapy, 2016

NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer, 2016

1. Nrf2 supports pancreatic tumor maintenance
2. Nrf2 inhibits oxidation of specific translational regulatory
   factors
3. Nrf2 promotes EGFR signaling to fuel cap-dependent mRNA
   translation
4. Combined targeting of AKT and glutathione synthesis
   inhibits pancreatic cancer

cellular localization,
biological function

• Enzymes

Database	Link
BRENDA - The Comprehensive Enzyme Information System	"URL":
KEGG Pathways	"URL":
Human Metabolome Database	"URL":

• Cell signaling and Ligand transport
• Structural proteins

REGULATION

DIAGNOSTIC USE