1) Patient History
birth year: 1931
weight: height: BMI: 17 lean
post-herpetic pain treated with analgesic pills (3/4 a day)
Ferritin: 28 ug/L
- Total 1,83
- Direct 0,42
- Indirect 1,41
Previous HSV infection
2) Molecular bases of symptoms
the higher the stimulus, the higher the spikes frequency...
but we get the same results when the intracellula ATP is low....
which local conditions can affect ATP synthesis?
- Less oxygen transport
- Less CoQ
- Less Cyt C
- low estrogens--> low heme synthesis
- iron deficiency
- Less glucose
3) Therapeutic approach aimed to correct metabolic alterations
Complex B Vitamins
After 4 weeks
Ferritin: 48 ug/L
Night and most of the day free of pain but...
around 11 a.m. pain requiring an analgesic pill
Serum cortisol at this time is at its nadir: breakfast carbohydrates are gone. Poor gluconeogenesis and sodium retention.
Pain by glucose nerve starvation
but also by lack of Na+ (Hyponatremia)
prevention of pain with saltine crackers at 10.30
After 8 weeks
Ferritin: 76 ug/L
No pain anymore at 11 even without additional crackers