Affamare il tumore
Conversazioni

Author: Gianpiero Pescarmona
Date: 08/07/2023

Description

Tutte le cellule che proliferano hanno bisogno di particolari aminoacidi (di cui il più importante è il triptofano).
La proteina del sangue più ricca di triptofano è il fibrinogeno che viene sintetizzato nel fegato stimolato da IL6 (interleukin 6) a sua volta indotta da TNFα.

Tutti gli interventi in grado di bloccare l'azione di IL6 e TNFα o di ridurre l'infiammazione e la disponibilità di triptofano rallentano la crescita tumorale

Dieta povera di triptofano: cercare qui gli alimenti con poco triptofano

orario___integratore_________________scopo______________commenti____________
MATTINA...
.PolyQ10energia, aiuta le cellule sane a rubare il cibo alle altre.
.Carnitina 500 mgbrucia grassi, aiuta le cellule sane a rubare il cibo alle altre.
.Colina 250/ Inositolo 250circolazione, reattivita' cellulare.
.Curcudyn forteantinfiammatorio, blocca TNFα.
.Cod liver Oil circa 1000/1500 mgantinfiammatorio blocca prostaglandine.
.Didrogyl gocce 1 ogni 10 kg pesoossa, sistema immunitario.
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PRANZO...
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PRIMA DI CENA...
.PolyQ10energia, aiuta le cellule sane a rubare il cibo alle altre.
.Curcudyn forteantinfiammatorio, blocca TNFα.
.Cod liver Oil circa 1000/1500 mgantinfiammatorio blocca prostaglandine.
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PRIMA DI CORICARSI...
.Magnesio 450/500mgaiuta il rilassamento e l'energia.
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effects of adalimumab tnf α

Effects of Anti-TNF-α Treatment on Lipid Profile in Patients with Active Rheumatoid Arthritis, 2006

  • In conclusion: Short anti-TNF-α treatment was associated with a significant increase of both total cholesterol and HDL cholesterol levels, and correlated with decreased disease activity.

PEA and cancer cells growth

Comments
2024-11-05T09:57:14 - Gianpiero Pescarmona

Relocalizing transcriptional kinases to activate apoptosis, 2024

Most drugs targeting kinases are designed to inhibit these enzymes, but there are certain situations in which it would be better to increase or retarget kinase activity instead. Sarott et al. designed a molecule to activate the transcription of key genes that are normally repressed in a particular human B cell lymphoma. In the cancer cells, transcription of these genes was inhibited by overactivity of the transcription factor BCL6 and its epigenetic co-repressors. The authors used a molecule linking an inhibitor of protein kinase CDK9 with a ligand of BCL6 to guide CDK9 and BCL6 into proximity at target genes. CDK9 was apparently released from the inhibitor complex sufficiently to phosphorylate RNA polymerase II and enhance transcriptional elongation. In a mouse model, this occurred with specificity for B cells responding abnormally to BCL6 without changing the overall activity of CDK9. Thus, repurposing protein kinase inhibitors to be part of such proximity inducers could have therapeutic potential. —L. Bryan Ray

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