Pescarmona GP Publications
The Author

Author: Gianpiero Pescarmona
Date: 07/10/2014

Description

Early Metabolomics Thesis 1967

Thesis on Red Blood Cells Metabolism 1967 -part 1
Thesis on Red Blood Cells Metabolism 1967 -part 2

...

Red Blood Cells glycolysis with and without oxygen. HbO2 is a stronger acid than Hb.
More H+

NAD+ + SubH2 --> NADH + H+ + Sub

and therefore less NADH and more NAD+ (NADH/NAD)

Effect of pyruvate on NADH/NAD+ ratio

All Papers

Papers GP Pescarmona

1970 Red Blood Cells metabolism

erythrocytes metabolism, pH effect on oxygen transport and erythrocyte metabolism, inborn erythrocyte metabolism defects: pyruvate kinase (PK) deficiency, glucose-6-phosphate-dehydrogenase (G6PD) deficiency, favism and role of divicine in the pathogenesis of haemolytic crisis. Erythrocyte GSH (glutathione) in talassemia, inborn erythrocyte enzyme defects, in type II diabetes

1980 Platelets metabolism, COX, GSH, Thrombosis

factors affecting platelet aggregation, Role of GSH in prostaglandin synthesis. Platelet aggregating factor (PAF): release from membrane phospholipids, inactivation, recycling. Calcium influx and ATP release during platelet aggregation. Platelet behavior in health and cardiovascular disease.

1990 Endothelial Cells metabolism, COX-1, NO-synthase, Lysosomes

drugs inhibiting platelet aggregation (COX-1 inhibitors: aspirin, indomethacin, PAF receptor inhibitors). Nitric Oxide (NO) donors of new synthesis as antiaggregants drugs. Factors affecting NO release in platelets and endothelial cells. Study of NO synthesis and NO synthasis activity in different cells: Plasmodium falciparum, Candida (invasion mechanisms), platelets (ageing, estrogens, thrombotic risk), endothelial cells (hypertension, erectile disfunction), cancer cells (proliferation). Role of Na+/H+ antiport in different pathologies. mechanisms of endosomal acidification and essential nutrients (iron, phosphorus, etc) influx into the cell. Cloroquine effect on lysosomal pH, on iNOS induction, on HIV in vitro replication.

2000 Modeling cell behavior, Role of acidic vesicles in Cells metabolism

Development of theoretical models and simulations to mimics in silico the in vivtro or in vivo experiments. This approach allows a better comprehension of the experimental results and a more effective planning of new experiments.

2010 Application of biochemical models to selected clinical case: osteoporosis, infections, pain, Vitamin D

Validation of the biochemical models by application to selected clinical cases.
Experimental works on: Bone Metabolism in health and osteoporosis, Vitamin D mechanism of action, MDR and mevalonate pathway.

Publications on Modeling and ICT

more details....

2014

The vitamin D receptor inhibits the respiratory chain, contributing to the metabolic switch that is essential for cancer cell proliferation.
Consiglio M, Destefanis M, Morena D, Foglizzo V, Forneris M, Pescarmona G, Silvagno F.
PLoS One. 2014 Dec 29;9(12):e115816. doi: 10.1371/journal.pone.0115816. eCollection 2014.
PMID: 25546457 Free PMC Article

2013

Zoledronic acid restores doxorubicin chemosensitivity and immunogenic cell death in multidrug-resistant human cancer cells.
Riganti C, Castella B, Kopecka J, Campia I, Coscia M, Pescarmona G, Bosia A, Ghigo D, Massaia M.
PLoS One. 2013 Apr 12;8(4):e60975. doi: 10.1371/journal.pone.0060975. Print 2013.
PMID: 23593363 Free PMC Article

Human protein cluster analysis using amino acid frequencies.
Vernone A, Berchialla P, Pescarmona G.
PLoS One. 2013 Apr 4;8(4):e60220. doi: 10.1371/journal.pone.0060220. Print 2013.
PMID: 23593177 Free PMC Article

Mitochondrial translocation of vitamin D receptor is mediated by the permeability transition pore in human keratinocyte cell line.
Silvagno F, Consiglio M, Foglizzo V, Destefanis M, Pescarmona G.
PLoS One. 2013;8(1):e54716. doi: 10.1371/journal.pone.0054716. Epub 2013 Jan 22.
PMID: 23349955 Free PMC Article

2012

Digoxin and ouabain induce the efflux of cholesterol via liver X receptor signalling and the synthesis of ATP in cardiomyocytes.
Campia I, Sala V, Kopecka J, Leo C, Mitro N, Costamagna C, Caruso D, Pescarmona G, Crepaldi T, Ghigo D, Bosia A, Riganti C.
Biochem J. 2012 Oct 15;447(2):301-11.
PMID: 22845468 Free Article

Platelet vitamin D receptor is reduced in osteoporotic patients.
D'Amelio P, Cristofaro MA, De Vivo E, Ravazzoli M, Grosso E, Di Bella S, Aime M, Cotto N, Silvagno F, Isaia G, Pescarmona GP.
Panminerva Med. 2012 Sep;54(3):225-31.
PMID: 22801440

Teriparatide increases the maturation of circulating osteoblast precursors.
D'Amelio P, Tamone C, Sassi F, D'Amico L, Roato I, Patanè S, Ravazzoli M, Veneziano L, Ferracini R, Pescarmona GP, Isaia GC.
Osteoporos Int. 2012 Apr;23(4):1245-53. doi: 10.1007/s00198-011-1666-2. Epub 2011 May 27.
PMID: 21617993

2011

A novel composition for in vitro and in vivo regeneration of skin and connective tissues.
Gennero L, De Siena R, Denysenko T, Roos MA, Calisti GF, Martano M, Fiobellot S, Panzone M, Reguzzi S, Gabetti L, Vercelli A, Cavallo G, Ricci E, Pescarmona GP.
Cell Biochem Funct. 2011 Jun;29(4):311-33. doi: 10.1002/cbf.1751.
PMID: 21491468

Bone and bone marrow pro-osteoclastogenic cytokines are up-regulated in osteoporosis fragility fractures.
D'Amelio P, Roato I, D'Amico L, Veneziano L, Suman E, Sassi F, Bisignano G, Ferracini R, Gargiulo G, Castoldi F, Pescarmona GP, Isaia GC.
Osteoporos Int. 2011 Nov;22(11):2869-77. doi: 10.1007/s00198-010-1496-7. Epub 2010 Nov 30.
PMID: 21116815

Modulation of doxorubicin resistance by the glucose 6-phosphate dehydrogenase activity
Manuela Polimeni, Claudia Voena, Joanna Kopecka, Chiara Riganti, Gianpiero Pescarmona, Amalia Bosia and Dario Ghigo
Biochem. J. (2011) Immediate Publication, doi:10.1042/BJ20102016 Fulltext

A LDL-masked liposomal-doxorubicin reverses drug resistance in human cancer cells.
Kopecka J, Campia I, Olivero P, Pescarmona G, Ghigo D, Bosia A, Riganti C.
J Control Release. 2011 Jan 20;149(2):196-205. doi: 10.1016/j.jconrel.2010.10.003. Epub 2010 Oct 12.
PMID: 20946921

2010

Iloprost modulates the immune response in systemic sclerosis.
D'Amelio P, Cristofaro MA, D'Amico L, Veneziano L, Roato I, Sassi F, Bisignano G, Saracco M, Pellerito R, Patanè S, Ferracini R, Pescarmona GP, Isaia GC.
BMC Immunol. 2010 Dec 15;11:62
PMID: 21159177 Free PMC Article

Analysis of vitamin D receptor expression and clinical correlations in patients with ovarian cancer.
Silvagno F, Poma CB, Realmuto C, Ravarino N, Ramella A, Santoro N, D'Amelio P, Fuso L, Pescarmona G, Zola P.
Gynecol Oncol. 2010 Oct;119(1):121-4. doi: 10.1016/j.ygyno.2010.06.008.
PMID: 20599260

Glioblastoma cancer stem cells: heterogeneity, microenvironment and related therapeutic strategies.
Denysenko T, Gennero L, Roos MA, Melcarne A, Juenemann C, Faccani G, Morra I, Cavallo G, Reguzzi S, Pescarmona G, Ponzetto A.
Cell Biochem Funct. 2010 Jun 10.
PMID: 20535838 Fulltext

The Role of Circulating Bone Cell Precursors in Fracture Healing.
D'Amelio P, Cristofaro MA, Grimaldi A, Ravazzoli M, Pluviano F, Grosso E, Pescarmona GP, Isaia GC.
Calcif Tissue Int. 2010 Apr 14. [Epub ahead of print]
Local Fulltext

Pluripotent plasticity of stem cells and liver repopulation.
Gennero L, Roos MA, Sperber K, Denysenko T, Bernabei P, Calisti GF, Papotti M, Cappia S, Pagni R, Aimo G, Mengozzi G, Cavallo G, Reguzzi S, Pescarmona GP, Ponzetto A.
Cell Biochem Funct. 2010 Mar 16. Local Fulltext

Mitochondrial Localization of Vitamin D Receptor in Human Platelets and Differentiated Megakaryocytes Silvagno F, De Vivo E, Attanasio A, Gallo V, Mazzucco G, Pescarmona GP
PLoS One. 2010 Jan 13;5(1):e8670.

Iron metabolism markers and haptoglobin phenotypes in susceptibility to HSV-1 or/and HSV-2 lesion relapses.
Gennero L, Roos MA, D'Amelio P, Denysenko T, Morra E, Sperber K, Ceroni V, Panzone M, Lesca F, De Vivo E, Grimaldi A, Gabetti ML, Ponzetto A, Pescarmona GP, Pugliese A.
Cell Biochem Funct. 2010 Jan 19.
Local Fulltext

2009

Geranylgeraniol prevents the cytotoxic effects of mevastatin in THP-1 cells, without decreasing the beneficial effects on cholesterol synthesis
I Campia, C Lussiana, G Pescarmona, D Ghigo, A Bosia and C Riganti
Br J Pharmacol. 2009 Dec;158(7):1777-86. Epub .
PMID: 19888963
Local Fulltext

Digoxin and ouabain induce P-glycoprotein by activating calmodulin kinase II and hypoxia-inducible factor-1alpha in human colon cancer cells.
Riganti C, Campia I, Polimeni M, Pescarmona G, Ghigo D, Bosia A.
Toxicol Appl Pharmacol. 2009 Jul 30. [Epub ahead of print]
PMID: 19647009
Local Fulltext

Artemisinin induces doxorubicin resistance in human colon cancer cells via calcium-dependent activation of HIF-1alpha and P-glycoprotein overexpression.
Riganti C, Doublier S, Viarisio D, Miraglia E, Pescarmona G, Ghigo D, Bosia A.
Br J Pharmacol. 2009 Mar 9. Fulltext

Digoxin and ouabain increase the synthesis of cholesterol in human liver cells.
Campia I, Gazzano E, Pescarmona G, Ghigo D, Bosia A, Riganti C.
Cell Mol Life Sci. 2009 Mar 15.
Local Fulltext

Targeted knowledge:interaction and rich user experience towards a scholarly communication that “lets”
Pescarmona GP, Giglia E
ELPUB 2009, Milan, 10-12 June 2009
[Local Fulltext]

The Pinball Machine and the Cloud:Using Rules to move from Information to Knowledge
Pescarmona GP, Zamuner F, Giglia E
Third Italian IA Summit, Forlì, 20-21 february 2009
[Local Fulltext]

2008

RhoA silencing reverts the resistance to doxorubicin in human colon cancer cells.
Doublier S, Riganti C, Voena C, Costamagna C, Aldieri E, Pescarmona G, Ghigo D, Bosia A.
Mol Cancer Res. 2008 Oct;6(10):1607-20.
[Local Fulltext]

Role of iron metabolism and oxidative damage in postmenopausal bone loss.
D'Amelio P, Cristofaro MA, Tamone C, Morra E, Di Bella S, Isaia G, Grimaldi A, Gennero L, Gariboldi A, Ponzetto A, Pescarmona GP, Isaia GC., Bone. 2008 Dec;43(6):1010-5. PDF , Local PDF

Activation of nuclear factor-kappa B pathway by simvastatin and RhoA silencing increases doxorubicin cytotoxicity in human colon cancer HT29 cells.
Riganti C, Doublier S, Costamagna C, Aldieri E, Pescarmona G, Ghigo D, Bosia A.
Mol Pharmacol. 2008 Aug;74(2):476-84. Epub 2008 May 7.
[Fulltext]

Estrogen deficiency increases osteoclastogenesis up-regulating T cells activity: a key mechanism in osteoporosis.
D'Amelio P, Grimaldi A, Di Bella S, Brianza SZ, Cristofaro MA, Tamone C, Giribaldi G, Ulliers D, Pescarmona GP, Isaia G.
Bone. 2008 Jul;43(1):92-100. Epub 2008 Mar 7.
[Fulltext]

Risedronate reduces osteoclast precursors and cytokine production in postmenopausal osteoporotic women.
D'Amelio P, Grimaldi A, Di Bella S, Tamone C, Brianza SZ, Ravazzoli MG, Bernabei P, Cristofaro MA, Pescarmona GP, Isaia G.
J Bone Miner Res. 2008 Mar;23(3):373-9.
[Fulltext]

2007

Asbestos induces nitric oxide synthesis in mesothelioma cells via Rho signaling inhibition.
Riganti C, Orecchia S, Silvagno F, Pescarmona G, Betta PG, Gazzano E, Aldieri E, Ghigo D, Bosia A.
Am J Respir Cell Mol Biol. 2007 Jun;36(6):746-56. Epub 2007 Feb 22.
[Fulltext]

Long-term exposure to dehydroepiandrosterone affects the transcriptional activity of the glucocorticoid receptor.
Saponaro S, Guarnieri V, Pescarmona GP, Silvagno F.
J Steroid Biochem Mol Biol. 2007 Feb;103(2):129-36. Epub 2006 Oct 27.
[Fulltext]

The Evolutionary Advantage of Being Conservative: The Role of Hysteresis. Pescarmona GP
In: DELSANTO, PIER PAOLO. Universality of Nonclassical Nonlinearity Applications to Non-Destructive Evaluations and Ultrasonics. p. 101-118, New York: Springer, ISBN/ISSN: 978-0-387-33860-6
[Fulltext]

2006

Immune system and bone metabolism: Does thymectomy influence postmenopausal bone loss in humans?
D'Amelio P, Grimaldi A, Bernabei P, Pescarmona GP, Isaia G.
Bone. 2006 Sep;39(3):658-65. Epub 2006 May 11.
[Fulltext]

Statins revert doxorubicin resistance via nitric oxide in malignant mesothelioma.
Riganti C, Orecchia S, Pescarmona G, Betta PG, Ghigo D, Bosia A.
Int J Cancer. 2006 Jul 1;119(1):17-27.
[Fulltext]

2005

Analysis and Prototyping of Biological Systems: the Abstract Biological Process Model.
DI LEVA A, BERCHI R, PESCARMONA GP, SONNESSA M (2005).
INTERNATIONAL JOURNAL OF INFORMATION TECHNOLOGY, vol. 2; p. 216-224, ISSN: 1305-2403
[Fulltext]

Analysis and Prototyping of Biological Systems.
DI LEVA A, BERCHI R, PESCARMONA GP, SONNESSA M (2005).
ENFORMATIKA, vol. 10; p. 1-6, ISSN: 1305-5313
[Fulltext]

2002

The life context: cells, nutrients and signals.
Pescarmona GP. In: CONDAT CA., BARUZZI A. Recent Research Development in Biophysical Chemistry. (pp. 69-90). TRIVANDRUM: RESEARCH SIGNPOST (INDIA) 2002
[Fulltext]

2001

Local interaction simulation approach for the response of the vascular system to metabolic changes of cell behavior
Scalerandi, M., Pescarmona, G.P., Delsanto, P.P., Capogrosso Sansone, B. 2001
Physical Review E - Statistical, Nonlinear, and Soft Matter Physics 63 (1 II), pp. 1-9
[Fulltext]

2000

Analysis of a "phase transition" from tumor growth to latency
Delsanto, P.P., Romano, A., Scalerandi, M., Pescarmona, G.P. 2000
Physical Review E - Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics 62 (2 B), pp. 2547-2554
[Fulltext]

A physical-based model for the simulation of neoplastic growth and metastasis
Magnano, M., Bongioannini, G., Lerda, W., Galvagno, M.B., Tondolo, E., Canale, G., Capogrosso, B., , Pescarmona, G.P. 2000
Journal of Surgical Oncology 74 (2), pp. 122-129
[Fulltext]

1999

Non-linear model of cancer growth and metastasis: A limiting nutrient as a major determinant of tumor shape and diffusion
Pescarmona, G.P., Scalerandi, M., Delsanto, P.P., Condat, C.A. 1999
Medical Hypotheses 53 (6), pp. 497-503 10
[Fulltext]

Nutrient competition as a determinant for cancer growth
Scalerandi, M., Romano, A., Pescarmona, G.P., Delsanto, P.P., Condat, C.A. 1999 Physical Review E - Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics 59 (2 PART B), pp. 2206-2217
[Fulltext]

1998

Model for diffusion and competition in cancer growth and metastasis
Pescarmona, G.P., Scalerandi, M., Delsanto, P.P., Condat, C.A. 1998
Materials Research Society Symposium - Proceedings 489, pp. 217-232
"[Fulltext]":

Movement of vesicles in eucariotic cells. Role of intravesicle protons as a fuel and modulation of their concentration by drugs or metabolic changes
Materials Research Society Symposium - Proceedings 489, pp. 205-210, 1998
[Fulltext]

Glutamate is involved in Axonal Transport

NADH/NAD and vesicles acidification

Patents

USE OF PARASYMPATHOLYTIC SUBSTANCES TO ENHANCE AND ACCELERATE STEM CELL DIFFERENTIATION, RELATED METHOD AND COMPOSITIONS 2007

ALBUMIN FOR TREATING CANCER AND A PHARMACEUTICAL COMPOSITION COMPRISING THE COMBINATION OF AN ANTI-NEOPLASTIC AGENT AND ALBUMIN 2007

DIFFERENTIATED IMMORTALISED CELL LINES CAPABLE OF PRODUCING ALBUMIN AND BLOOD COAGULATION FACTORS, METHODS OF PREPARING THEREOF FROM A LEUKAEMIA CELL LINE AND USES THEREOF 2006

CULTURE MEDIUM AND PHARMACEUTICAL COMPOSITION FOR REGENERATING CARTILAGE TISSUE, A METHOD, USES AND PRODUCTS RELATED THERETO 2006

VERFAHREN ZUR VERBESSERUNG DER LAGERFAEHIGKEIT VON TROMBOZYTENPRAEPARATEN 1986

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