Transthyretin
Thyroid Hormones Transport

Author: Gianpiero Pescarmona
Date: 17/11/2009

Description

DEFINITION

Transthyretin is a serum and cerebrospinal fluid carrier of the thyroid hormone thyroxine (T4) and retinol. This is how transthyretin gained its name, trans ports thy roxine and retin ol.

External links not available on Wikipedia have to be added here

DatabaseLink
WikigenesURL
GeneCards"URL":
iHOP"URL":
OMIM"URL":
Entrez Gene"URL":

CHEMICAL STRUCTURE AND IMAGES

When relevant for the function

  • Primary structure

  • Secondary structure

Each monomer is a 127-residue polypeptide rich in beta sheet structure

  • Tertiary structure
  • Quaternary structure

TTR is a 55-kDa homotetramer.

SYNTHESIS AND TURNOVER

mRNA synthesis
protein synthesis
post-translational modifications
degradation

CELLULAR FUNCTIONS

cellular localization,
biological function

  • Enzymes
  • Cell signaling and Ligand transport
  • Structural proteins

REGULATION

DIAGNOSTIC USE

Attachments
fileuserdate
TTHY-TBG4-RT4.gifgp17/11/2009
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