SREBP (Sterol Regulatory Element Binding Protein)
Transcription Factors

Author: Gianpiero Pescarmona
Date: 2010-04-26

Description

DEFINITION

Sterol regulatory element binding protein are transcription factors that bind to the sterol regulatory element DNA sequence TCACNCCAC.

Database	Gene	Gene	Gene	Gene	Gene	Gene
Wikigenes	SREBP1	SREBP2	SCAP	INSIG	S1P/MBTPS1	S2P/MBTPS2
GeneCards	"SREBP1":	"SREBP2":	"SCAP":	"INSIG":

CHEMICAL STRUCTURE AND IMAGES

When relevant for the function

Primary structure
Secondary structure
Tertiary structure
- PDB
Quaternary structure

Protein Aminoacids Percentage
The Protein Aminoacids Percentage gives useful information on the local environment and the metabolic status of the cell (starvation, lack of essential AA, hypoxia)

Model (Width 600 px)

SYNTHESIS AND TURNOVER

mRNA synthesis

protein synthesis
post-translational modifications

degradation

CELLULAR FUNCTIONS

cellular localization,

Mol Cell Endocrinol. 2009 May 6;303(1-2):1-6. Epub 2009 Jan 22.

New functions of cholesterol binding proteins. 2009

Liu JP.

Department of Immunology, Monash University Central Clinical School, Prahran, Victoria, Australia. jun-ping.liu@med.monash.edu.au
Abstract

Cholesterol is an essential component of eukaryotic cell membranes with an important role in signal transduction. Although cholesterol can operate to auto-regulate its own disposal via gene transcriptional mechanisms, glucose also binds to the same cholesterol-binding transcription factors to regulate gene expression. Different sterol binding proteins bind different lipids to regulate both lipid homeostasis and antigen presentation. This mini-review examines the recently reported new functions of cholesterol binding proteins in cholesterol homeostasis, function and trafficking, and explores the molecular mechanisms whereby sterol sensors respond to glucose and other ligands to regulate diverse cellular functions in metabolism. Several new models are proposed from studies on a range of sterol binding proteins including Insig, SCAP, LXR, HMG-CoAR, NPC1 and NPC2.

biological function