Tryptophan 2,3-dioxygenase (TDO)
Tryptophan

DEFINITION

is an enzyme mainly located in liver cells. This enzyme catalyzes the degradation of L-tryptophan to N-formylkynurenine.

THE GENE

Database	Link
Wikigenes	TDO2
GeneCards	"TDO2":
Your Favorite Gene Sigma	"TDO2":

CHEMICAL STRUCTURE AND IMAGES

When relevant for the function

• Primary structure
• Secondary structure
• Tertiary structure
  • PDB
• Quaternary structure

Protein Aminoacids Percentage
The Protein Aminoacids Percentage gives useful information on the local environment and the metabolic status of the cell (starvation, lack of essential AA, hypoxia)

Protein Aminoacids Percentage (Width 700 px)

SYNTHESIS AND TURNOVER

mRNA synthesis

Hypoxia

Acclimatization to hypoxia modulates the tryptophan 2,3-dioxygenase activity in rats exposed to simulated high altitude. 1991

Glucocorticoids

protein synthesis

post-translational modifications
degradation

CELLULAR FUNCTIONS

cellular localization,
biological function

• Enzymes

Database	Link
BRENDA - The Comprehensive Enzyme Information System	"URL":
KEGG Pathways	"URL":
Human Metabolome Database	"URL":

• Cell signaling and Ligand transport
• Structural proteins

REGULATION

DIAGNOSTIC USE