Author: Gianpiero Pescarmona
IUPAC recommended ring lettering (left) and atom numbering (right) of the steroid skeleton. The four rings A-D form a sterane core (more on structure and nomenclature).
Control Analysis of Adrenal Steroidogenesis 2003
Steroids are derived from cholesterol.
Synthesis takes place part in cytoplasm and part in mitochondria.
Steroid sulfatase locally releases free DHEA from serum DHeEAS.
Cholesterol import is mediated by
The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders 2011
KEGG PATHWAYS: Steroid hormones Pathway (Free on the Web)
Enzymes involved in steroid hormones synthesis display different activity in different individuals according to
Additional figure on enzymes involved in steroids synthesis
The following list links to the available information on this topic:
Regulation depends on a feedback loop that involves:
a deeper insight
Oxygen availability as a regulatory factor of androgen synthesis by adrenocortical cells. 1993
C21-Steroid hormone metabolism
Steroid Metabolism Enzymes with Links
Androgen and estrogen metabolism
Inhibition of 11ss-hydroxysteroid dehydrogenase type 1 as a promising therapeutic target. 2007
Delayed Treatment with Dehydroepiandrosterone Sulfate Enhances Gene Expression Related to Neuroplasticity 2003
Steroid hormones and Type II Diabetes
ADRENAL ANDROGENS in Endotext