Polyol Pathway
Glucose Metabolism

Author: Gianpiero Pescarmona
Date: 21/10/2007

Description

In the polyol pathway glucose is reduced by aldose reductase to sorbitol. Sorbitol dehydrogenase can then oxidize sorbitol to fructose.

Aldose reductase has a wide specificity

Aldose reductase has a high Km for both Glucose and NADPH

h4. Flow trough this pathway lead to low NADPH/NADP and high NADH/NAD ratio

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